Background To date, the coronavirus disease 2019 (COVID-19) caused more than 2.6 million deaths all around the world. Risk factors for mortality remain unclear. The primary aim was to determine the independent risk factors for 28-day mortality. Materials and Methods In this retrospective cohort study, critically ill patients (≥ 18 years) who were admitted to the intensive care unit due to COVID-19 were included. Patient characteristics, laboratory data, radiologic findings, treatments, and complications were analyzed in the study. Results A total of 249 patients (median age 71, 69.1% male) were included in the study. 28-day mortality was 67.9% (n = 169). The median age of deceased patients was 75 (66–81). Of them, 68.6% were male. Cerebrovascular disease, dementia, chronic kidney disease, and malignancy were significantly higher in the deceased group. In the multivariate analysis, sepsis/septic shock (OR, 15.16, 95% CI, 3.96–58.11, p < 0.001), acute kidney injury (OR, 4.73, 95% CI, 1.55–14.46,p = 0.006), acute cardiac injury (OR, 9.76, 95% CI, 1.84–51.83, p = 0.007), and chest CT score higher than 15 (OR, 4.49, 95% CI, 1.51-13.38, p = 0.007) were independent risk factors for 28-day mortality. Conclusion Early detection of the risk factors and the use of chest CT score might improve the outcomes in patients with COVID-19.
【저자키워드】 COVID-19, SARS-CoV-2, Risk factors, Critical care, Mortality, tomography, 【초록키워드】 coronavirus disease, intensive care, 28-day mortality, Acute kidney injury, Chronic kidney disease, outcome, risk factor, Acute cardiac injury, Dementia, Shock, Characteristics, Chest CT, Early detection, male, Patient, death, Complication, disease, Analysis, Deceased, cerebrovascular, malignancy, Critically ill patient, retrospective cohort study, Factor, 95% CI, median age, laboratory data, independent risk factor, material, IMPROVE, Result, analyzed, radiologic, caused, determine, significantly higher, patients with COVID-19, 【제목키워드】 28-day mortality, risk factor, Characteristics, clinical, Critically ill patient, retrospective cohort study,