A novel betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which caused a large respiratory outbreak in Wuhan, China in December 2019, is currently spreading across many countries globally. Here, we show that a TMPRSS2-expressing VeroE6 cell line is highly susceptible to SARS-CoV-2 infection, making it useful for isolating and propagating SARS-CoV-2. Our results reveal that, in common with SARS- and Middle East respiratory syndrome-CoV, SARS-CoV-2 infection is enhanced by TMPRSS2.
All Keywords
【저자키워드】 SARS-CoV-2, coronavirus, outbreak, VeroE6, TMPRSS2, 【초록키워드】 SARS-COV-2 infection, Middle East, acute respiratory syndrome, novel Betacoronavirus, cell line, susceptible, country, Wuhan, China, caused, 【제목키워드】 Isolation, enhanced, TMPRSS2-expressing cell,
【저자키워드】 SARS-CoV-2, coronavirus, outbreak, VeroE6, TMPRSS2, 【초록키워드】 SARS-COV-2 infection, Middle East, acute respiratory syndrome, novel Betacoronavirus, cell line, susceptible, country, Wuhan, China, caused, 【제목키워드】 Isolation, enhanced, TMPRSS2-expressing cell,