Coronaviruses belong to a large family of viruses that can cause disease outbreaks ranging from the common cold to acute respiratory syndrome. Since 2003, three zoonotic members of this family evolved to cross species barriers infecting humans and resulting in relatively high case fatality rates (CFR). Compared to Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV, CFR = 10%) and pandemic Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2, CFR = 6%), the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) has scored the highest CFR (approximately 35%). In this review, we systematically summarize the current state of scientific knowledge about MERS-CoV, including virology and origin, epidemiology, zoonotic mode of transmission, and potential therapeutic or prophylactic intervention modalities.
【저자키워드】 coronavirus, Epidemiology, MERS-CoV, zoonotic disease, 【초록키워드】 SARS-CoV-2, pandemic, SARS-CoV, knowledge, Human, Intervention, Transmission, Prophylactic, virus, coronavirus 2, outbreak, zoonotic, therapeutic, Case fatality rate, cross, common cold, respiratory, CFR, disease, Middle East, acute respiratory syndrome, infecting, highest, resulting, scored, 【제목키워드】 respiratory, Middle East, Science, state,