Background: The SARS-CoV-2 pandemic has involved a severe increase of cases worldwide in a wide range of populations. The aim of the present investigation was to evaluate recent insights about COVID-19 infection in children, infants and pregnant subjects. Methods: a literature overview was performed including clinical trials, in vitro studies, reviews and published guidelines regarding the present paper topic. A descriptive synthesis was performed to evaluate recent insights and the effectiveness of therapies for SARS-CoV-2 infection in children, infants and pregnant subjects. Results: Insufficient data are available regarding the relationship between COVID-19 and the clinical risk of spontaneous abortion and premature foetus death. A decrease in the incidence of COVID-19 could be correlated to a minor expression of ACE2 in childrens’ lungs. At present, a modulation of the dose-effect posology for children and infants is necessary. Conclusions: Pregnant vertical transmission has been hypothesised for SARS-CoV-2 infection. Vaccines are necessary to achieve mass immunity for children and also pregnant subjects.
【저자키워드】 SARS-CoV-2, therapy, children, Coronavirus-19, Pandemics, pregnant, 【초록키워드】 COVID-19, ACE2, Immunity, SARS-COV-2 infection, SARS-CoV-2 pandemic, clinical trials, Transmission, Infant, COVID-19 infection, Lungs, Effectiveness, death, Premature, expression, spontaneous abortion, In vitro studies, Foetus, Topic, modulation, clinical risk, populations, decrease, evaluate, involved, was performed, subjects, correlated, hypothesised, incidence of COVID-19, Insufficient, 【제목키워드】 COVID-19, Infant, recent, insight,