Background: The increased production of carbon monoxide (CO) in sepsis has been proven, but the blood level variations of carboxyhemoglobin (COHb) as a potential evolutionary parameter of COVID-19 and sepsis/septic shock have yet to be determined. This study aims to evaluate the serum level variation of COHb as a potential evolutionary parameter in COVID-19 critically ill patients and in bacterial sepsis. Materials and method: A prospective and observational study was conducted on two groups of patients: the bacterial sepsis group ( n = 52) and the COVID-19 group ( n = 52). We followed paraclinical parameters on Day 1 (D1) and Day 5 (D5) of sepsis/ICU admission for COVID-19 patients. Results: D1 of sepsis: statistically significant positive correlations between: COHb values and serum lactate ( p = 0.024, r = 0.316), and total bilirubin ( p = 0.01, r = 0.359). In D5 of sepsis: a statistically significant positive correlations between: COHb values and procalcitonin (PCT) ( p = 0.038, r = 0.402), and total bilirubin ( p = 0.023, r = 0.319). D1 of COVID-19 group: COHb levels were statistically significantly positively correlated with C-reactive protein CRP values ( p = 0.003, r = 0.407) and with PCT values ( p = 0.022, r = 0.324) and statistically significantly negatively correlated with serum lactate values ( p = 0.038, r = −0.285). Conclusion: COHb variation could provide rapid information about the outcome of bacterial sepsis/septic shock, having the advantages of a favorable cost-effectiveness ratio, and availability as a point-of-care test.
【저자키워드】 COVID-19, Sepsis, liver dysfunction, carboxyhemoglobin, Lactate, 【초록키워드】 Variation, C-reactive protein, procalcitonin, outcome, point-of-care, Shock, information, Admission, Bacterial sepsis, COVID-19 patients, Bacterial, Blood level, Critically ill patient, total bilirubin, Serum level, positive correlation, COVID-19 group, material, parameter, PCT, evaluate, significantly, Day, conducted, correlated, two group, statistically significant, statistically, CRP value, positively correlated, serum lactate, 【제목키워드】 novel, endogenous, Level,