An increasing amount of evidence indicates a relatively high prevalence of superinfections associated with coronavirus disease 2019 (COVID-19), including invasive aspergillosis, but the underlying mechanisms remain to be characterized. In the present study, to better understand the biological impact of superinfection, we determine and compare the host transcriptional response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) versus Aspergillus superinfection, using a model of reconstituted human airway epithelium. Our analyses reveal that both simple infection and superinfection induce strong deregulation of core components of innate immune and inflammatory responses, with a stronger response to superinfection in the bronchial epithelial model compared to its nasal counterpart. Our results also highlight unique transcriptional footprints of SARS-CoV-2 Aspergillus superinfection, such as an imbalanced type I/type III IFN, and an induction of several monocyte and neutrophil associated chemokines, that could be useful for the understanding of Aspergillus -associated COVID-19 and also the management of severe forms of aspergillosis in this specific context.
【저자키워드】 COVID-19, SARS-CoV-2, Aspergillus, invasive aspergillosis, transcriptional profiling, 【초록키워드】 coronavirus disease, coronavirus, Inflammatory responses, neutrophil, Infection, nasal, chemokines, monocyte, Prevalence, management, IFN, Host transcriptional response, Aspergillus, epithelial, mechanism, Evidence, innate immune, Analysis, Human airway epithelium, acute respiratory syndrome, component, deregulation, invasive, highlight, transcriptional, form, characterized, indicate, determine, unique, induce, 【제목키워드】 Human, response, Model, superinfection, Profiling, Context,