The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic effects daily dental work. Therefore, infection control measures are necessary to prevent infection of dental personnel during dental treatments. The use of a preprocedural mouth rinse with chlorhexidine (CHX), cetylpyridinium chloride (CPC), or hydrogen peroxide (H 2 O 2 ) solution for 30–60 s may reduce the viral load and may protect the personnel in a dental practice. In the present study the virucidal effect of the mouth rinsing solutions ViruProX ® with 0.05% CPC and 1.5% H 2 O 2 and BacterX ® pro containing 0.1% CHX, 0.05% CPC, and 0.005% sodium fluoride (F – ) was investigated in vitro. The mouth rinsing solutions successfully inactivated infectious SARS-CoV-2 particles, the causative agent of coronavirus disease 2019 (COVID-19), within 30 s. To determine the effective components, CHX, CPC, H 2 O 2 , and a combination of CHX and CPC, were tested against SARS-CoV-2 in addition. While a combination of CPC and CHX as well as CPC alone led to a significant reduction of infectious viral particles, H 2 O 2 and CHX alone had no virucidal effect against SARS-CoV-2. It can be assumed that preprocedural rinsing of the mouth with ViruProX ® or BacterX ® pro will reduce the viral load in the oral cavity and could thus lower the transmission of SARS-CoV-2 in dental practice.
【저자키워드】 SARS-CoV-2, cetylpyridinium chloride, mouth rinsing solution, ViruProX®, BacterX® pro, 【초록키워드】 COVID-19, coronavirus disease, infection control, coronavirus, pandemic, sodium, Infection, in vitro, Viral load, virucidal, hydrogen peroxide, inactivated, Combination, Viral particles, reduction, acute respiratory syndrome, fluoride, components, measure, SARS-CoV-2 particles, while, transmission of SARS-CoV-2, Effect, Prevent, effective, PROTECT, tested, addition, investigated, determine, reduce, had no, assumed, 【제목키워드】 solution, mouth, rinsing, Pro,