Various aspects of our physiology and immune response to pathogens are under 24 h circadian control and its role in clinical and research practice is becoming increasingly recognized. Severe acute respiratory syndrome coronavirus-2, the causative agent of Coronavirus disease 2019 (COVID-19) has affected millions of people to date. Cross-disciplinary approaches and collaborative efforts have led to an unprecedented speed in developing novel therapies and vaccines to tackle the COVID-19 pandemic. Circadian misalignment and sleep disruption have a profound impact on immune function and subsequently on the ability of individuals to combat infections. This review summarizes the evidence on the interplay between circadian biology, sleep and COVID-19 with the aim to identify areas of translational potentials that may inform diagnostic and therapeutic strategies in this pandemic.
【저자키워드】 Dexamethasone, SARS-CoV-2, Vaccine, coronavirus, Healthcare workers, 【초록키워드】 COVID-19, Coronavirus disease 2019, immune response, pandemic, therapy, COVID-19 pandemic, diagnostic, infections, pathogen, Research, immune function, therapeutic strategy, Coronavirus-2, Evidence, acute respiratory syndrome, individual, Collaborative effort, identify, affected, approach, increasingly, translational, 【제목키워드】 COVID-19,