Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly contagious infection that may break the healthcare system of several countries. Here, we aimed at presenting a critical view of ongoing drug repurposing efforts for COVID-19 as well as discussing opportunities for development of new treatments based on current knowledge of the mechanism of infection and potential targets within. Finally, we also discuss patent protection issues, cost effectiveness and scalability of synthetic routes for some of the most studied repurposing candidates since these are key aspects to meet global demand for COVID-19 treatment.
All Keywords
【저자키워드】 COVID-19, Drug repurposing, SARS-CoV-2, Drug discovery, drug targets, replication cycle, 【초록키워드】 Treatment, Coronavirus disease 2019, coronavirus, knowledge, Infection, Cost effectiveness, target, Critical, mechanism, Healthcare system, contagious infection, acute respiratory syndrome, effort, candidate, caused, presenting, 【제목키워드】 targets, molecular,
【저자키워드】 COVID-19, Drug repurposing, SARS-CoV-2, Drug discovery, drug targets, replication cycle, 【초록키워드】 Treatment, Coronavirus disease 2019, coronavirus, knowledge, Infection, Cost effectiveness, target, Critical, mechanism, Healthcare system, contagious infection, acute respiratory syndrome, effort, candidate, caused, presenting, 【제목키워드】 targets, molecular,