Human endogenous retroviruses (HERV) have been implicated in the pathogenesis of several nervous system disorders including multiple sclerosis and amyotrophic lateral sclerosis. The toxicity of HERV-derived RNAs and proteins for neuronal cells has been demonstrated. The involvement of HERV in the pathogenesis of currently incurable diseases might offer new treatment strategies based on the inhibition of HERV activities by small molecules or therapeutic antibodies.
All Keywords
【저자키워드】 multiple sclerosis, monoclonal antibodies, Amyotrophic lateral sclerosis, human endogenous retrovirus,
【저자키워드】 multiple sclerosis, monoclonal antibodies, Amyotrophic lateral sclerosis, human endogenous retrovirus,