COVID-19 has plagued the world since it was first identified in December 2019. Previous systematic reviews and meta-analysis were limited by various factors such as the usage of non-peer reviewed data and were also limited by the lack of clinical data on a global scale. ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread across the globe at unprecedented speed and is showing no signs of slowing down. The outbreak of coronavirus disease 2019 (COVID-19) has led to significant health burden in infected patients especially in those with underlying comorbidities. The aim of this study was to evaluate the correlation between comorbidities and their role in the exacerbation of disease in COVID-19 patients leading to fatal outcomes. A systematic review was conducted using data from MEDLINE, Scopus, Web of Science, and EMBASE databases published from 1 December 2019 to 15 September 2020. Fifty-three articles were included in the systematic review. Of those 53 articles, 8 articles were eligible for meta-analysis. Hypertension, obesity, and diabetes mellitus were identified to be the most prevalent comorbidities in COVID-19 patients. Our meta-analysis showed that cancer, chronic kidney diseases, diabetes mellitus, and hypertension were independently associated with mortality in COVID-19 patients. Chronic kidney disease was statistically the most prominent comorbidity leading to death. However, despite having high prevalence, obesity was not associated with mortality in COVID-19 patients.
【저자키워드】 COVID-19, SARS-CoV-2, Comorbidity, 【초록키워드】 coronavirus disease, Meta-analysis, coronavirus, Mortality, obesity, Cancer, Comorbidities, Diabetes Mellitus, systematic review, hypertension, database, Spread, Prevalence, outcomes, Health, outbreak, death, Kidney disease, correlation, disease, COVID-19 patients, COVID-19 patient, chronic, acute respiratory syndrome, Factor, Web of Science, Clinical data, article, chronic kidney diseases, articles, lack, evaluate, globe, conducted, infected patient, statistically, eligible, most prevalent comorbidity, non-peer reviewed, 【제목키워드】 review,