[저자] Quentin Philippot, Arnaud Fekkar, Adrian Gervais, Tom Le Voyer, Leonoor S. Boers, Clément Conil, Lucy Bizien, Justin de Brabander, Jan Willem Duitman, Alessia Romano, Jérémie Rosain, Marion Blaize, Mélanie Migaud, Maxime Jeljeli, Boualem Hammadi, Aurore Desmons, Astrid Marchal, ArtDECO consortiumNossentEsther J.SarisAnnoDe VriesHederMeijboomLilian J.BlokSiebe G.SchuurmanAlex R.ReijndersTom D. Y.HugenholtzF.VallejoJuan J. GarciaBontkesHettyVlaarAlexander P. J.WiersingaJoostLutterRenévan der PollTomBogaardHarm JanKullbergRobert F. J.ZhangShiqiNossentEsther J.HeunksLeo M. A.TuinmanPieter RoelBontaPeter I., Esther J. Nossent, Anno Saris, Heder De Vries, Lilian J. Meijboom, Siebe G. Blok, Alex R. Schuurman, Tom D. Y. Reijnders, F. Hugenholtz, Juan J. Garcia Vallejo, Hetty Bontkes, Alexander P. J. Vlaar, Joost Wiersinga, René Lutter, Tom van der Poll, Harm Jan Bogaard, Robert F. J. Kullberg, Shiqi Zhang, Esther J. Nossent, Leo M. A. Heunks, Pieter Roel Tuinman, Peter I. Bonta, COVID HGE consortiumAbelLaurentAl-MuhsenSalehAriasAndrés A.BogunovicDusanBolzeAlexandreBousfihaAhmed A.MansouriDavoodMeytsIsabellede DiegoRebeca PerezSancho-ShimizuVanessaSpaanAndrás N.TangyeStuart G.ZhangShen-YingSuHelen C., Laurent Abel, Saleh Al-Muhsen, Andrés A. Arias, Dusan Bogunovic, Alexandre Bolze, Ahmed A. Bousfiha, Davood Mansouri, Isabelle Meyts, Rebeca Perez de Diego, Vanessa Sancho-Shimizu, András N. Spaan, Stuart G. Tangye, Shen-Ying Zhang, Helen C. Su, Julien Mayaux, Qian Zhang, Emmanuelle Jouanguy, Raphael Borie, Bruno Crestani, Charles Edouard Luyt, Homa Adle-Biassette, Damien Sene, Bruno Megarbane, Aurélie Cobat, Paul Bastard, Lieuwe D. J. Bos, Jean-Laurent Casanova, Anne Puel
[Category] 대상포진,
[Article Type] article
[Source] pmc
Autoantibodies (auto-Abs) neutralizing type I interferons (IFNs) are found in the blood of at least 15% of unvaccinated patients with life-threatening COVID-19 pneumonia. We report here the presence of auto-Abs neutralizing type I IFNs in the bronchoalveolar lavage (BAL) of 54 of the 415 unvaccinated patients (13%) with life-threatening COVID-19 pneumonia tested. The 54 individuals with neutralizing auto-Abs in the BAL included 45 (11%) with auto-Abs against IFN-α2, 37 (9%) with auto-Abs against IFN-ω, 54 (13%) with auto-Abs against IFN-α2 and/or ω, and five (1%) with auto-Abs against IFN-β, including three (0.7%) with auto-Abs neutralizing IFN-α2, IFN-ω, and IFN-β, and two (0.5%) with auto-Abs neutralizing IFN-α2 and IFN-β. Auto-Abs against IFN-α2 also neutralize the other 12 subtypes of IFN-α. Paired plasma samples were available for 95 patients. All seven patients with paired samples who had detectable auto-Abs in BAL also had detectable auto-Abs in plasma, and one patient had auto-Abs detectable only in blood. Auto-Abs neutralizing type I IFNs are, therefore, present in the alveolar space of at least 10% of patients with life-threatening COVID-19 pneumonia. These findings suggest that these auto-Abs impair type I IFN immunity in the lower respiratory tract, thereby contributing to hypoxemic COVID-19 pneumonia. Supplementary Information The online version contains supplementary material available at 10.1007/s10875-023-01512-9.
All Keywords
【저자키워드】 COVID-19, SARS-CoV-2, Cytokines, type I interferons,