Purpose: COVID-19 has been associated with a dysregulated inflammatory response. Patients who have received solid-organ transplants are more susceptible to infections in general due to the use of immunosuppressants. We investigated factors associated with mechanical ventilation and outcomes in solid-organ transplant recipients with COVID-19. Materials and Methods: We conducted a retrospective cohort study of all solid-organ transplant recipients admitted with a diagnosis of COVID-19 in our 23-hospital health system over a 1-month period. Descriptive statistics were used to describe hospital course and laboratory results and bivariate comparisons were performed on variables to determine differences. Results: Twenty-two patients with solid-organ transplants and COVID-19 were identified. Eight patients were admitted to the ICU, of which 7 were intubated. Admission values of CRP (p = 0.045) and N/L ratio (p = 0.047) were associated with the need for mechanical ventilation. Seven patients (32%) died during admission, including 86% (n = 6) of patients who received mechanical ventilation. Conclusions: In solid-organ transplant recipients with COVID-19, initial CRP and N/L ratio were associated with need for mechanical ventilation.
【저자키워드】 Critical care, Respiratory failure, infections, Endotracheal intubation, 【초록키워드】 COVID-19, mechanical ventilation, hospital, Infection, CRP, outcome, immunosuppressants, ICU, comparison, Patient, health system, Admission, Inflammatory response, N/L ratio, retrospective cohort study, Factor, Intubated, Descriptive statistics, material, recipient, variable, susceptible, initial, Course, performed, died, investigated, conducted, were used, determine, dysregulated, diagnosis of COVID-19, laboratory result, solid-organ transplant, with COVID-19, 【제목키워드】 COVID-19, Transplant, Solid,