The current SARS-CoV-2 pandemic has emerged as an international challenge with strong medical and socioeconomic impact. The spectrum of clinical manifestations of SARS-CoV-2 is wide, covering asymptomatic or mild cases up to severe and life-threatening complications. Critical courses of SARS-CoV-2 infection are thought to be driven by the so-called “cytokine storm”, derived from an excessive immune response that induces the release of proinflammatory cytokines and chemokines. In recent years, non-coding RNAs (ncRNAs) emerged as potential diagnostic and therapeutic biomarkers in both inflammatory and infectious diseases. Therefore, the identification of SARS-CoV-2 miRNAs and host miRNAs is an important research topic, investigating the host–virus crosstalk in COVID-19 infection, trying to answer the pressing question of whether miRNA-based therapeutics can be employed to tackle SARS-CoV-2 complications. In this review, we aimed to directly address ncRNA role in SARS-CoV-2-immune system crosstalk upon COVID-19 infection, particularly focusing on inflammatory pathways and cytokine storm syndromes.
【저자키워드】 COVID-19, SARS-CoV-2, Cytokine storm, immune response, miRNAs, lncRNAs, Inflammatory response, ncRNAs, 【초록키워드】 Biomarker, Diseases, SARS-COV-2 infection, SARS-CoV-2 pandemic, diagnostic, chemokines, Asymptomatic, COVID-19 infection, International, therapeutic, Research, complications, Inflammatory, clinical manifestation, Proinflammatory cytokine, Topic, life-threatening, host miRNA, excessive immune response, non-coding RNA, ncRNA, thought, Course, question, induce, driven by, “cytokine storm”, inflammatory pathway, mild case, SARS-CoV-2 miRNA, 【제목키워드】 review, microRNA, response, narrative,