Inflammatory and immune processes are defensive mechanisms that aim to remove harmful agents. As a response to infections, inflammation and immune response contribute to the pathophysiological mechanisms of diseases. Coronavirus disease 2019 (COVID-19), whose underlying mechanisms remain not fully elucidated, has posed new challenges for the knowledge of pathophysiology. Chiefly, the inflammatory process and immune response appear to be unique features of COVID-19 that result in developing a hyper-inflammatory syndrome, and air pollution, the world’s largest health risk factor, may partly explain the behaviour and fate of COVID-19. Understanding the mechanisms involved in the progression of COVID-19 is of fundamental importance in order to avoid the late stage of the disease, associated with a poor prognosis. Here, the role of the inflammatory and immune mediators in COVID-19 pathophysiology is discussed.
【저자키워드】 COVID-19, Inflammation, Cytokine storm, SARS-CoV2, immune response, Genetic polymorphism, Pollution, 【초록키워드】 Coronavirus disease 2019, Diseases, knowledge, progression, risk factor, immune, Health, infections, pathophysiology, understanding, mechanism, Inflammatory, syndrome, poor prognosis, pathophysiological mechanism, late stage, inflammatory process, feature, involved, the disease, contribute, unique, explain, 【제목키워드】 response, lesson,