Key Points Question Is treatment of COVID-19 at a dedicated hospital associated with improved care processes and outcomes? Findings In this cohort study of 5504 patients with COVID-19, lower mortality rates were found in dedicated COVID-19 hospitals vs other hospitals. Meaning Results of this study suggest that treatment at dedicated COVID-19 hospitals may be associated with reducing in-hospital mortality; this model may be useful during future pandemics. Importance Early in the SARS-CoV-2 pandemic, the M Health Fairview Hospital System established dedicated hospitals for establishing cohorts and caring for patients with COVID-19, yet the association between treatment at COVID-19–dedicated hospitals and mortality and complications is not known. Objective To analyze the mortality rate and complications associated with treatment at the COVID-19–dedicated hospitals. Design, Setting, and Participants This retrospective cohort study evaluated data prospectively collected from March 1, 2020, through June 30, 2021, from 11 hospitals in Minnesota, including 2 hospitals created solely to care for patients with COVID-19. Data obtained included demographic characteristics, treatments, and outcomes of interest for all patients with a confirmed COVID-19 infection admitted to this hospital system during the study period. Exposures Patients were grouped based on whether they received treatment from 1 of the 2 COVID-19–dedicated hospitals compared with the remainder of the hospitals within the hospital system. Main Outcomes and Measures Multivariate analyses, including risk-adjusted logistic regression and propensity score matching, were performed to evaluate the primary outcome of in-hospital mortality and secondary outcomes, including complications and use of COVID-specific therapeutics. Results There were 5504 patients with COVID-19 admitted during the study period (median age, 62.5 [IQR, 45.0-75.6] years; 2854 women [51.9%]). Of these, 2077 patients (37.7%) (median age, 63.4 [IQR, 50.7-76.1] years; 1080 men [52.0%]) were treated at 1 of the 2 COVID-19–dedicated hospitals compared with 3427 (62.3%; median age, 62.0 [40.0-75.1] years; 1857 women (54.2%) treated at other hospitals. The mortality rate was 11.6% (n = 241) at the dedicated hospitals compared with 8.0% (n = 274) at the other hospitals ( P < .001). However, risk-adjusted in-hospital mortality was significantly lower for patients in the COVID-19–dedicated hospitals in both the unmatched group (n = 2077; odds ratio [OR], 0.75; 95% CI, 0.59-0.95) and the propensity score–matched group (n = 1317; OR, 0.78; 95% CI, 0.58-0.99). The rate of overall complications in the propensity score–matched group was significantly lower (OR, 0.81; 95% CI, 0.66-0.99) and the use of COVID-19–specific therapeutics including deep vein thrombosis prophylaxis (83.9% vs 56.9%; P < .001), high-dose corticosteroids (56.1% vs 22.2%; P < .001), remdesivir (61.5% vs 44.5%; P < .001), and tocilizumab (7.9% vs 2.0; P < .001) was significantly higher. Conclusions and Relevance In this cohort study, COVID-19–dedicated hospitals had multiple benefits, including providing high-volume repetitive treatment and isolating patients with the infection. This experience suggests improved in-hospital mortality for patients treated at dedicated hospitals owing to improved processes of care and supports the use of establishing cohorts for future pandemics. This cohort study compares the mortality rate and complications associated with treatment in hospitals dedicated to the care of patients with COVID-19 vs other hospitals.
【초록키워드】 Corticosteroid, COVID-19, Treatment, pandemic, Mortality, Tocilizumab, hospital, Infection, Remdesivir, outcome, cohort study, hospitals, Cohort, Patient, Pandemics, Complication, Logistic regression, mortality rate, women, Care, in-hospital mortality, association, propensity score matching, exposure, Odds ratio, demographic characteristics, Support, In-hospital, retrospective cohort study, High-dose, Primary outcome, 95% CI, Secondary outcomes, median age, study period, multivariate, measure, participant, Confirmed COVID-19 infection, lower mortality, finding, significantly lower, Thrombosis prophylaxis, men, System, objective, setting, Result, performed, collected, evaluate, evaluated, treated, reducing, significantly higher, analyses, Importance, patients treated, patients with COVID-19, Point, Relevance, the SARS-CoV-2, 【제목키워드】 COVID-19, Other, Process,