In the ongoing COVID-19 pandemic, all COVID-19 patients are naïve patients as it is the first-time humans have been exposed to the SARS-CoV-2 virus. As with exposure to many viruses, individuals with pre-existing, compromised immune systems may be at increased risk of developing severe symptoms and/or dying because of (SARS-CoV-2) infection. To learn more about such individuals, we conducted a search and review of published reports on the clinical characteristics and outcomes of COVID-19 patients with pre-existing, compromised immune systems. Here we present our review of patients who possess pre-existing primary antibody deficiency (PAD) and those who are organ transplant recipients on maintenance immunosuppressants. Our review indicates different clinical outcomes for the patients with pre-existing PAD, depending on the underlying causes. For organ transplant recipients, drug-induced immune suppression alone does not appear to enhance COVID-19 mortality risk – rather, advanced age, comorbidities, and the development of secondary complications appears required.
【초록키워드】 viruses, SARS-CoV-2, Clinical characteristics, COVID-19 pandemic, Human, Infection, Comorbidities, risk, Organ transplant, immune system, outcome, immunosuppressants, Clinical outcome, Patient, Complication, Immune suppression, COVID-19 mortality, COVID-19 patient, deficiency, increased risk, recipients, causes, individual, advanced age, naïve, recipient, immune systems, primary antibody, ENhance, the patient, required, conducted, appear, indicate, individuals, severe symptom, the SARS-CoV-2 virus, 【제목키워드】 COVID-19, review, clinical, report, Compromised,