Coronavirus Disease 2019 (COVID-19) emerges as a global pandemic and there is a lack of evidence about the clinical course and outcome of patients on maintenance hemodialysis (MHD). Here we conducted a retrospective longitudinal study aimed to analyze the clinical features and outcome of MHD patients hospitalized with COVID-19. Of 3126 inpatients with COVID-19 at 3 Branches of Wuhan Tongji Hospital from Jan 18th to Mar 9th, 2020, 19 patients were undergoing maintenance hemodialysis. Among the 19 MHD patients with COVID-19, 6 patients (31.6%) died, and 13 patients (68.4%) were able to be discharged. Baseline characteristics, clinical courses, laboratory findings, and dynamic trajectories of major laboratory markers were compared between survivors and nonsurvivors. According to our findings, MHD patients with COVID-19 who experienced non-surviving outcome had more elevated CRP, IL6 and procalcitonin as well as fibrinogen levels at various points compared to survivors. Thus the dysregulation of immune response as well as coagulation abnormalities might be highly involved in the pathological process of COVID-19, contributing to the poor prognosis in MHD patients.
【저자키워드】 COVID-19, SARS-CoV-2, outcome, Clinical features, maintenance hemodialysis patients, 【초록키워드】 immune response, IL6, CRP, procalcitonin, Laboratory, Coagulation, global pandemic, Clinical course, Hemodialysis, Characteristics, Survivors, Wuhan, Patient, trajectory, patients, clinical feature, marker, Evidence, retrospective, dysregulation, Inpatient, nonsurvivors, poor prognosis, Tongji Hospital, abnormality, survivor, courses, lack, died, involved, elevated, conducted, contributing to, discharged, fibrinogen level, had more, patients hospitalized, patients with COVID-19, with COVID-19, 【제목키워드】 Hemodialysis, clinical, Patient, retrospective, Course,