Lung disorders are a leading cause of morbidity and death worldwide. For many disease conditions, no effective and curative treatment options are available. Mesenchymal stromal cell (MSC)-based therapy is one of the cutting-edge topics in medical research today. It offers a novel and promising therapeutic option for various acute and chronic lung diseases due to its potent and broad-ranging immunomodulatory activities, bacterial clearance, tissue regeneration, and proangiogenic and antifibrotic properties, which rely on both cell-to-cell contact and paracrine mechanisms. This review covers the sources and therapeutic potential of MSCs. In particular, a total of 110 MSC-based clinical applications, either completed clinical trials with safety and early efficacy results reported or ongoing worldwide clinical trials of pulmonary diseases, are systematically summarized following preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines, including acute/viral pulmonary disease, community-acquired pneumonia (CAP), chronic obstructive pulmonary disease (COPD), bronchopulmonary dysplasia (BPD), interstitial lung diseases (ILD), chronic pulmonary fibrosis, bronchiolitis obliterans syndrome (BOS) and lung cancer. The results of recent clinical studies suggest that MSCs are a promising therapeutic approach for the treatment of lung diseases. Nevertheless, large-scale clinical trials and evaluation of long-term effects are necessary in further studies.
【초록키워드】 Treatment, Meta-analysis, Efficacy, clinical trial, therapy, pulmonary fibrosis, systematic review, Interstitial lung disease, MSCs, lung cancer, COPD, Lung diseases, morbidity, Research, death, mechanisms, disease, ILD, community-acquired pneumonia, pulmonary disease, Bacterial, clinical study, Therapeutic approach, chronic lung disease, MSC, pulmonary diseases, Contact, therapeutic option, stromal cell, tissue regeneration, therapeutic potential, syndrome, disorder, curative treatment, immunomodulatory activities, clearance, offer, Effect, effective, reported, conditions, chronic obstructive, bronchopulmonary dysplasia, paracrine, 【제목키워드】 review, clinical, Cell-based therapy,