Background There is clinical importance to investigate the disease progression through potential biomarkers of SARS-CoV-2 infection. In the present study, we aim to evaluate the significance of inflammatory markers in different categories of COVID-19 in admitted patients. Methods In a single-center, observational study of 50 in-hospital patients who were diagnosed with COVID-19 and admitted to the intensive care unit of a tertiary care hospital in Peshawar, infection biomarkers, including hs-CRP, serum ferritin, serum creatinine, ALT, ALP, cardiac troponin-I, and IL-6 were analyzed. Results The median age was 61.3 years. 70% (35) were male while 30% (15) were female. We noted significantly increased hs-CRP (9.32 mg/dL ± 10.03) and ferritin levels (982.3 ng/ml ± 601.9). A noteworthy increase was observed in neutrophil count (11.05 × 10 9 /L) and a decrease was observed in lymphocyte count (0.27 × 10 9/ L) ( P < 0.05), and the platelet count was borderline decreased (244.1 × 10 9 /L). IL-6 levels were markedly increased in all admitted patients (100.2 pg/ml ± 122.2 pg/ml). Conclusion The serum levels of CRP, troponin-I, ALP, ALT, serum creatinine, and ferritin are markedly increased in COVID-19 patients. Increased CRP and ferritin levels were also associated with secondary bacterial infection and poor clinical outcomes.
【초록키워드】 COVID-19, Biomarkers, intensive care, IL-6, SARS-COV-2 infection, hospital, Infection, CRP, ferritin, progression, clinical outcomes, Lymphocyte count, male, female, Platelet, Inflammatory marker, Care, patients, COVID-19 patients, Potential biomarker, ALT, Admitted Patient, serum creatinine, Serum ferritin, Serum level, median age, neutrophil count, single-center, secondary bacterial infection, decrease, significantly increased, Result, analyzed, evaluate, the disease, category, Increased, ALP, diagnosed with COVID-19, ferritin level, IL-6 level, in-hospital patient, 【제목키워드】 experience, Profiling, with COVID-19,