Background Inflammatory adverse events following COVID-19 vaccination are being reported amidst the growing concerns regarding vaccine’s immunogenicity and safety, especially in patients with pre-existing inflammatory conditions. Methods Multinational case series of patients diagnosed with an ocular inflammatory event within 14 days following COVID-19 vaccination collected from 40 centres over a 3 month period in 2021. Results Seventy patients presented with ocular inflammatory events within 14 days following COVID-19 vaccination. The mean age was 51 years (range, 19–84 years). The most common events were anterior uveitis ( n = 41, 58.6%), followed by posterior uveitis ( n = 9, 12.9%) and scleritis ( n = 7, 10.0%). The mean time to event was 5 days and 6 days (range, 1–14 days) after the first and second dose of vaccine, respectively. Among all patients, 36 (54.1%) had a previous history of ocular inflammatory event. Most patients ( n = 48, 68.6%) were managed with topical corticosteroids. Final vision was not affected in 65 (92.9%), whereas 2 (2.9%) and 3 (4.3%) had reduction in visual acuity reduced by ≤3 lines and > 3 lines, respectively. Reported complications included nummular corneal lesions ( n = 1, 1.4%), cystoid macular oedema ( n = 2, 2.9%) and macular scarring ( n = 2, 2.9%). Conclusion Ocular inflammatory events may occur after COVID-19 vaccination. The findings are based on a temporal association that does not prove causality. Even in the possibility of a causal association, most of the events were mild and had a good visual outcome.
【저자키워드】 COVID-19, coronavirus disease, SARS-CoV-2, vaccination, immunomodulatory, Uveitis, Ocular inflammation, 【초록키워드】 Vaccine, Corticosteroids, outcome, COVID-19 vaccination, adverse event, Patient, Complication, Mild, age, patients, association, Inflammatory, lesion, second dose, inflammatory conditions, oedema, visual acuity, ocular, event, Corneal, Result, collected, reported, diagnosed, Most patient, reduced, case sery, occur, not affected, reduction in, scarring, 【제목키워드】 Inflammatory, event, case sery,