Background Anxiety, depression and reduction of quality of life (QoL) are common in people with multiple sclerosis (pwMS). Fear of getting sick from COVID-19, government’s lockdown and the imposed social distancing might have had an impact on psychological distress and QoL. Objectives The aim of our study was to investigate anxiety, depression and QoL changes in pwMS during SARS-CoV-2 outbreak and lockdown in Italy. Methods 67 pwMS with a previous (less than 6 months) neuropsychological evaluation before SARS-CoV-2 outbreak (T0) were re-evaluated at the time of the outbreak and lockdown in Italy (T1). They underwent a clinical and neurological evaluation and completed the State-Trait Anxiety Inventory (STAI-Y1), the Beck Depression Inventory second edition (BDI-II), and Multiple Sclerosis Quality of Life-54 (MsQoL-54) at T0 and T1. Benjamini–Hochberg procedure was applied to control the false discovery rate. Results BDI-II and STAI-Y1 scores did not change between T0 and T1. At T1, MsQoL-54 scores were higher on the satisfaction with sexual life and the social function subscales, and lower on the limitation due to emotional problems subscale. Conclusions This is the first study that evaluated mood and QoL levels before and during the lockdown due to COVID-19 pandemic in pwMS. No worsening of anxiety and depression levels was found. Contrariwise some improvements were noted on QoL, the most reliable regarding the sexual satisfaction and the social function.
【저자키워드】 COVID-19, Anxiety, Depression, multiple sclerosis, lockdown, Sexual satisfaction, 【초록키워드】 SARS-CoV-2, social distancing, COVID-19 pandemic, Italy, improvement, outbreak, Psychological distress, Quality of life, Quality, fear, Satisfaction, neurological, emotional, reduction, false discovery rate, Beck, worsening, problem, Multiple, sclerosis, objective, inventory, Result, evaluated, applied, less, changes in, sick, Benjamini–Hochberg procedure, 【제목키워드】 COVID-19 pandemic, Italian, consequence,