Background: Despite rescue therapy, more than 30% of patients with acute severe ulcerative colitis (ASUC) require colectomy. Tofacitinib is a rapidly acting JAK inhibitor with proven efficacy in ulcerative colitis. Tofacitinib may provide additional means for preventing colectomy in patients with ASUC. Methods: A retrospective case-control study was performed evaluating the efficacy of tofacitinib induction in biologic-experienced patients admitted with ASUC requiring IV corticosteroids. Tofacitinib patients were matched 1:3 to controls according to gender and date of admission. Using Cox regression adjusted for disease severity, we estimated the 90-day risk of colectomy. Rates of complications and steroid dependence were examined as secondary outcomes. Results: Forty patients who received tofacitinib were matched 1:3 to controls (n=113). Tofacitinib was protective against colectomy at 90 days compared to matched controls (HR 0.28, 95% CI 0.10, 0.81, P = 0.018 ). When stratifying according to treatment dose, 10mg three times daily (HR 0.11 95% CI 0.02, 0.56, P=0.008 ) was protective, while 10mg twice daily was not significantly protective (HR 0.66, 95% CI 0.21, 2.09, P=0.5 ). Rate of complications and steroid dependence were similar between tofacitinib and controls. Discussion: Tofacitinib with concomitant IV corticosteroids may be an effective induction strategy in biologic-experienced patients hospitalized with ASUC. Prospective trials are needed to identify the safety, optimal dose, frequency, and duration of tofacitinib for ASUC.
【저자키워드】 ulcerative colitis, colectomy, Tofacitinib,