Graphical Abstract This study identified T cell signatures associated to rheumatoid arthritis patients undergoing various treatments. Tofacitinib-treated patients exhibit an accumulation of senescent T cells. Moreover, tofacitinib impaired T-cell activation, proliferation and effector functions in vitro , triggering senescent pathways. These effects may contribute to tofacitinib’s clinical success and side effects in rheumatoid arthritis.
All Keywords
【저자키워드】 T cells, rheumatoid arthritis, immunosenescence, JAK inhibitor, Tofacitinib,
【저자키워드】 T cells, rheumatoid arthritis, immunosenescence, JAK inhibitor, Tofacitinib,