Biologic immunomodulatory medications have rapidly expanded in the previous decades, providing new treatment options for individuals with a spectrum of oncologic, allergic, rheumatologic, and neurologic conditions. Biologic therapies alter immune function and can impair key host defense mechanisms, resulting in secondary immunodeficiency and increased infectious risks. Biologic medications can increase general risk for upper respiratory tract infections, but can also be associated with unique infectious risks due to distinct mechanisms of action. With their widespread use, providers in every area of medicine will likely care for individuals receiving biologic therapies and understanding of their potential infectious complications can help mitigate these risks. This practical review discusses the infectious implications of biologics by class of medication and provides recommendations regarding the evaluation and screening both prior to therapy initiation and while the patient is receiving the medication. With this knowledge and background, providers can reduce risk while patients receive the treatment benefits of these biologic medications.
【저자키워드】 Infection, Immunosuppression, biologics, secondary immunodeficiency, Biologic therapy,