The emergence of the novel human coronavirus SARS-CoV-2 in Wuhan, China has caused a worldwide epidemic of respiratory disease (COVID-19). Vaccines and targeted therapeutics for treatment of this disease are currently lacking. Here we report a human monoclonal antibody that neutralizes SARS-CoV-2 (and SARS-CoV) in cell culture. This cross-neutralizing antibody targets a communal epitope on these viruses and may offer potential for prevention and treatment of COVID-19. Vaccines and targeted therapeutics for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are currently lacking. Here, the authors report a human monoclonal antibody capable of neutralizing both authentic SARS-CoV and SARS-CoV-2 by targeting a common epitope.
【저자키워드】 Virology, Immunotherapy, 【초록키워드】 COVID-19, Treatment, SARS-CoV-2, coronavirus, antibody, SARS-CoV, virus, coronavirus SARS-CoV-2, Epidemic, Cell culture, Human monoclonal antibody, Respiratory disease, target, Neutralizing, epitope, disease, acute respiratory syndrome, offer, neutralize, Wuhan, China, caused, cross-neutralizing, 【제목키워드】 SARS-COV-2 infection, Human monoclonal antibody,