Visual Abstract Highlights • Cardiorenal tissues and/or endothelial cells express ACE2 and BSG • ACE2/TMPRSS2 polarizes to lung/epithelium and BSG to vessel/endothelium • Expression of SARS-CoV-2 host genes are mainly relatively stable with age • Notable exceptions were; ACE2 which decreases with age in some tissues and, • BSG which increases with age in endothelial cells Summary Vascular and cardiovascular inflammation and thrombosis occur in patients with severe coronavirus disease-2019 (COVID-19). Advancing age is the most significant risk factor for severe COVID-19. Using transcriptomic databases, the authors found that: 1) cardiovascular tissues and endothelial cells express putative genes for severe acute respiratory syndrome coronavirus-2 infection, including angiotensin-converting enzyme 2 ( ACE2 ) and basigin ( BSG ); 2) severe acute respiratory syndrome coronavirus-2 receptor pathways ACE2 /transmembrane serine protease 2 and BSG /peptidylprolyl isomerase B(A) polarize to lung/epithelium and vessel/endothelium, respectively; 3) expression of host genes is relatively stable with age; and 4) notable exceptions are ACE2 , which decreases with age in some tissues, and BSG , which increases with age in endothelial cells, suggesting that BSG expression in the vasculature may explain the heightened risk for severe disease with age.
【저자키워드】 COVID-19, cardiovascular, endothelial cells, age, BSG, Basigin, TMPRSS2, Transmembrane serine protease 2, ACE2, angiotensin converting enzyme 2, COVID-19, coronavirus disease-2019, SARS-CoV-2, severe acute respiratory syndrome-coronavirus-2, ADAM17, ADAM metallopeptidase domain 17, CTSB, cathepsin B, CTSL, cathepsin L, GTEx, Genotype-Tissue Expression, PBMC, peripheral blood mononuclear cells, PPIA, peptidylprolyl isomerase A, PPIB, peptidylprolyl isomerase B, 【초록키워드】 SARS-CoV-2, Inflammation, ACE2, coronavirus, thrombosis, severe COVID-19, Infection, risk, risk factor, angiotensin-converting enzyme 2, Patient, pathway, vasculature, receptor, BSG, expression, Coronavirus-2, Endothelial cell, severe disease, Visual, acute respiratory syndrome, tissue, tissues, serine protease, Express, transcriptomic, decrease, increase, occur, notable, explain, host gene, Advancing, putative gene, 【제목키워드】 SARS-CoV-2, Basigin, increase,