Pre-existing immunity modulates responses to mRNA boosters

Published on
Journal: Cell Reports
[저자] Tanushree Dangi, Sarah Sanchez, Min Han Lew, Bakare Awakoaiye, Lavanya Visvabharathy, Justin M. Richner, Igor J. Koralnik, Pablo Penaloza-MacMaster
[Category] 대상포진,
PMC URL    Pubmed URL    DOI URL    [DOI] 10.1016/j.celrep.2023.112167    
[Article Type] Article
[Source] PMC

Dangi et al. show that pre-existing antibodies accelerate the clearance of vaccine antigen via Fc-dependent mechanisms, limiting the amount of antigen available to prime B cell responses after mRNA boosters. This finding suggests that transient downmodulation of antibody effector mechanisms may improve the serial re-utilization of mRNA-LNPs.

All Keywords
【저자키워드】 SARS-CoV-2, mRNA vaccines, Omicron variant, pre-existing immunity, antibody effector functions, updated vaccines,