Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is now a global pandemic that has wreaked havoc globally, which has put a heavy toll on public health, lives, and the world economy. Vaccination is considered as one of the greatest successes in medical history. Based on prior experience with the development of SARS-CoV vaccines, all COVID-19 vaccines must be subjected to the tests for protective effects and harmful risks derived from antibody-dependent enhancement that may contribute to augmented infectivity and/or eosinophilic infiltration. The SARS-CoV-2 vaccine is now being developed urgently in several different ways. China is regarded as one of the world’s leading countries in SARS-CoV-2 vaccine development, up to date the last inactivated vaccine international clinical (Phase III) trial was launched in the United Arab Emirates by Sinopharm China National Biotec Group (CNBG). In this review, we outline the current status of vaccine development against clinically relevant SARS-CoV-2 strains, anticipating that such attempts would help create efficacious and sage SARS-CoV-2 vaccines.
【저자키워드】 COVID-19, SARS-CoV-2, coronavirus, clinical trial, Vaccines, 【초록키워드】 public health, Coronavirus disease 2019, Vaccine development, COVID-19 vaccine, Trial, SARS-CoV, Antibody-dependent enhancement, risk, SARS-CoV-2 vaccines, SARS-CoV-2 vaccine, global pandemic, China, Inactivated vaccine, International, group, protective effect, Sinopharm, infiltration, phase, acute respiratory syndrome, help, SARS-CoV-2 strains, country, caused, clinically, contribute, United Arab Emirate, 【제목키워드】 SARS-CoV-2 vaccine, current,