SARS-CoV-2 belongs to the coronavirus family. Comparing genomic features of viral genomes of coronavirus family can improve our understanding about SARS-CoV-2. Here we present the first pan-genome analysis of 3,932 whole genomes of 101 species out of 4 genera from the coronavirus family. We found that a total of 181 genes in the pan-genome of coronavirus family, among which only 3 genes, the S gene, M gene and N gene, are highly conserved. We also constructed a pan-genome from 23,539 whole genomes of SARS-CoV-2. There are 13 genes in total in the SARS-CoV-2 pan-genome. All of the 13 genes are core genes for SARS-CoV-2. The pan-genome of coronaviruses shows a lower level of diversity than the pan-genomes of other RNA viruses, which contain no core gene. The three highly conserved genes in coronavirus family, which are also core genes in SARS-CoV-2 pan-genome, could be potential targets in developing nucleic acid diagnostic reagents with a decreased possibility of cross-reaction with other coronavirus species.
【저자키워드】 COVID-19, SARS-CoV-2, Genome, Diversity, Pangenomics, 【초록키워드】 coronavirus, nucleic acid, RNA viruses, target, N gene, genomic, S gene, Analysis, viral genome, whole genome, M gene, Genes, feature, IMPROVE, conserved, core gene, diagnostic reagent, the SARS-CoV-2, 【제목키워드】 coronavirus, Analysis,