Varicella-Zoster Virus Infection of Primary Human Spinal Astrocytes Produces Intracellular Amylin, Amyloid-β, and an Amyloidogenic Extracellular Environment

Varicella-zoster virus infection of astrocytes produces intracellular amylin, amyloid-β, amyloid, and an extracellular amyloidogenic environment due, in part, to amyloidogenic viral peptides. These findings indicate that infection may contribute to the toxic amyloid burden, accelerating amyloid-associated disease progression.