Highlights • Mechanisms of T cell homeostasis with age are different in mouse and men. • T cell generation in the human adult is derived from peripheral T cell proliferation. • Peripheral fitness selection during proliferation causes unevenness in the repertoire. • Thymus rejuvenation may restore lymphopenia but not repertoire evenness. • Next generation sequencing will provide information on repertoire diversity with age.
【저자키워드】 aging, T cells, immunosenescence, T cell receptor repertoire, thymus,