ABSTRACT The coronavirus disease 2019 (COVID-19) pandemic has created a global health- and economic crisis. Detection of antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which causes COVID-19 by serological methods is important to diagnose a current or resolved infection. In this study, we applied a rapid COVID-19 IgM/IgG antibody test and performed serology assessment of antibody response to SARS-CoV-2. In PCR-confirmed COVID-19 patients (n = 45), the total antibody detection rate is 92% in hospitalized patients and 79% in non-hospitalized patients. The total IgM and IgG detection is 63% in patients with <2 weeks from disease onset; 85% in non-hospitalized patients with >2 weeks disease duration; and 91% in hospitalized patients with >2 weeks disease duration. We also compared different blood sample types and suggest a higher sensitivity by serum/plasma over whole blood. Test specificity was determined to be 97% on 69 sera/plasma samples collected between 2016-2018. Our study provides a comprehensive validation of the rapid COVID-19 IgM/IgG serology test, and mapped antibody detection patterns in association with disease progress and hospitalization. Our results support that the rapid COVID-19 IgM/IgG test may be applied to assess the COVID-19 status both at the individual and at a population level.
【저자키워드】 COVID-19, SARS-CoV-2, Antibody test, IgM and IgG, serology assessment, disease severity and duration, 【초록키워드】 coronavirus disease, coronavirus, pandemic, Hospitalization, serology, antibody, Antibody Response, Infection, Test, detection, sensitivity, specificity, Health, Antibody detection, Whole blood, IgM/IgG, Patient, serology test, serological, disease, diagnose, association, Support, acute respiratory syndrome, blood sample, serum/plasma, performed, collected, applied, provide, was determined, hospitalized patient, cause, mapped, resolved, 【제목키워드】 Antibody Response, IgM/IgG, patients with COVID-19,