Abstract Virus-virus interactions influence the epidemiology of respiratory infections. However, the impact of viruses causing upper respiratory infections on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication and transmission is currently unknown. Human rhinoviruses cause the common cold and are the most prevalent respiratory viruses of humans. Interactions between rhinoviruses and cocirculating respiratory viruses have been shown to shape virus epidemiology at the individual host and population level. Here, we examined the replication kinetics of SARS-CoV-2 in the human respiratory epithelium in the presence or absence of rhinovirus. We show that human rhinovirus triggers an interferon response that blocks SARS-CoV-2 replication. Mathematical simulations show that this virus-virus interaction is likely to have a population-wide effect as an increasing prevalence of rhinovirus will reduce the number of new coronavirus disease 2019 cases. Human rhinovirus triggers an innate immune response that blocks severe acute respiratory syndrome coronavirus 2 replication within human respiratory epithelium. Given the high prevalence of human rhinovirus, this effect might cause a population-wide reduction in new coronavirus disease 2019 infections.
【저자키워드】 SARS-CoV-2, rhinovirus, virus-virus interactions, 【초록키워드】 respiratory infections, coronavirus, innate immune response, Epidemiology, Human, Transmission, virus, Replication, Prevalence, infections, rhinovirus, respiratory virus, humans, common cold, disease, interferon response, SARS-CoV-2 replication, New coronavirus, Interaction, Trigger, acute respiratory syndrome, upper respiratory infection, population level, human respiratory epithelium, replication kinetics, Human rhinovirus, block, Host, prevalent, shown, examined, absence, reduce, reduction in, 【제목키워드】 COVID-19, Human, coronavirus 2, respiratory, block,