Severe acute respiratory syndrome coronavirus (SARS-CoV-2) has produced significant health emergencies worldwide, resulting in the declaration by the World Health Organization of the coronavirus disease 2019 (COVID-19) pandemic. Acute respiratory syndrome seems to be the most common manifestation of COVID-19. A high proportion of patients require intensive care unit admission and mechanical ventilation (MV) to survive. It has been well established that angiotensin-converting enzyme type 2 (ACE2) is the primary cellular receptor for SARS-CoV-2. ACE2 belongs to the renin–angiotensin system (RAS), composed of several peptides, such as angiotensin II (Ang II) and angiotensin (1-7) (Ang-(1-7)). Both peptides regulate muscle mass and function. It has been described that SARS-CoV-2 infection, by direct and indirect mechanisms, affects a broad range of organ systems. In the skeletal muscle, through unbalanced RAS activity, SARS-CoV-2 could induce severe consequences such as loss of muscle mass, strength, and physical function, which will delay and interfere with the recovery process of patients with COVID-19. This article discusses the relationship between RAS, SARS-CoV-2, skeletal muscle, and the potentially harmful consequences for skeletal muscle in patients currently infected with and recovering from COVID-19.
【저자키워드】 COVID-19, SARS-CoV-2, ICU, Muscle wasting, ICUAW, 【초록키워드】 coronavirus disease, ACE2, coronavirus, pandemic, intensive care, mechanical ventilation, SARS-COV-2 infection, peptide, RAS, Patient, peptides, mechanisms, Ang II, muscle mass, Admission, Angiotensin-converting enzyme, regulate, organ systems, World Health Organization, Skeletal muscle, health emergency, acute respiratory syndrome, syndrome, cellular receptor, Affect, physical, consequence, RAS activity, produced, resulting, described, proportion, composed, induce, interfere, patients with COVID-19, recovering from COVID-19, 【제목키워드】 muscle, couple, Effect,