Coronavirus 2 (CoV) Severe Acute Respiratory Syndrome (SARS-CoV2) is causing a highly infectious pandemic pneumonia. Coronaviruses are positive sense single-stranded RNA viruses that infect several animal species, causing symptoms that range from those similar to the common cold to severe respiratory syndrome. The Angiotensin Converting Enzyme 2 (ACE2) is the SARS-CoV2 functional receptor. Measures are currently undertaken worldwide to control the infection to avoid disruption of the social and economic equilibrium, especially in countries with poor healthcare resources. In a guarded optimistic view, we hope that the undertaken preventive and treatment measures will at least contribute to contain viral diffusion, attenuate activity, or even eliminate SARS-CoV2. In this review, we discuss emerging perspectives for prevention/treatment of COVID-19 infection. In addition to vaccines under development, passive immunization is an open opportunity since patients develop neutralizing antibodies. A full spectrum of potential drugs for COVID-19 infections could in turn affect virus binding or enzymatic activities involved in viral replication and transcription. Furthermore, clinical trials are currently evaluating the safety and efficacy of anti-inflammatory drugs, such as tocilizumab. Bioinformatics may allow characterization of specific CD8+ and CD4+ T cell responses; thus, CoV2 T cells’ frequency can be correlated with the disease severity and outcome. Combinatorial antibody phage display may be empowered to identify the immune repertoire of CoV2-specific neutralizing antibodies.
【저자키워드】 Treatment, prevention, immune system, SARS-CoV2 infection, outbreak, 【초록키워드】 Efficacy, ACE2, Vaccine, Anti-inflammatory drugs, SARS-CoV2, clinical trial, pandemic, Tocilizumab, Pneumonia, Neutralizing antibodies, antibody, severity, Transcription, Infection, Symptom, drug, outcome, virus, coronavirus 2, immunization, immune, Replication, COVID-19 infection, healthcare, Patient, CoV, receptor, common cold, respiratory, CD4+ T cell, binding, Frequency, angiotensin, enzymatic activity, Perspective, measure, severe respiratory syndrome, single-stranded RNA virus, positive, CD8+, diffusion, infect, resources, Affect, country, identify, develop, involved, addition, the disease, functional, contribute, in viral, correlated, turn, attenuate, 【제목키워드】 review,