Growing interest in hypertension—one of the main factors characterizing the cardiometabolic syndrome (CMS)—and anti-hypertensive drugs raised from the emergence of a new coronavirus, SARS-CoV-2, responsible for the COVID19 pandemic. The virus SARS-CoV-2 employs the Angiotensin-converting enzyme 2 (ACE2), a component of the RAAS (Renin-Angiotensin-Aldosterone System) system, as a receptor for entry into the cells. Several classes of synthetic drugs are available for hypertension, rarely associated with severe or mild adverse effects. New natural compounds, such as peptides, might be useful to treat some hypertensive patients. The main feature of ACE inhibitory peptides is the location of the hydrophobic residue, usually Proline, at the C-terminus. Some already known bioactive peptides derived from marine resources have potential ACE inhibitory activity and can be considered therapeutic agents to treat hypertension. Peptides isolated from marine vertebrates, invertebrates, seaweeds, or sea microorganisms displayed important biological activities to treat hypertensive patients. Here, we reviewed the anti-hypertensive activities of bioactive molecules isolated/extracted from marine organisms and discussed the associated molecular mechanisms involved. We also examined ACE2 modulation in sight of SARS2-Cov infection prevention.
【저자키워드】 COVID-19, ACE2, hypertension, ACE inhibitors, renin-angiotensin-aldosterone system, marine peptides, sea organisms, cardiometabolic syndrome, 【초록키워드】 SARS-CoV-2, COVID19, pandemic, peptide, drug, molecular mechanism, virus, activity, adverse effects, cells, peptides, Infection prevention, Mild, RAAS, therapeutic agent, receptor, resource, compounds, New coronavirus, cardiometabolic, microorganism, ACE, in sight, Factor, modulation, enzyme, residue, syndrome, treat, organism, hydrophobic, inhibitory activity, C-terminus, vertebrates, invertebrates, inhibitory, hypertensive patients, biological activity, System, responsible, examined, involved, raised, New, anti-hypertensive drug, 【제목키워드】 SARS-CoV-2, prevention, drug, cardiovascular, origin, ACE, role, Potential,