An enigmatic localized pneumonia escalated into a worldwide COVID-19 pandemic from Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). This review aims to consolidate the extensive biological minutiae of SARS-CoV-2 which requires decipherment. Having one of the largest RNA viral genomes, the single strand contains the genes ORF1ab, S, E, M, N and ten open reading frames. Highlighting unique features such as stem-loop formation, slippery frameshifting sequences and ribosomal mimicry, SARS-CoV-2 represents a formidable cellular invader. Hijacking the hosts translational engine, it produces two polyprotein repositories (pp1a and pp1ab), armed with self-cleavage capacity for production of sixteen non-structural proteins. Novel glycosylation sites on the spike trimer reveal unique SARS-CoV-2 features for shielding and cellular internalization. Affording complexity for superior fitness and camouflage, SARS-CoV-2 challenges diagnosis and vaccine vigilance. This review serves the scientific community seeking in-depth molecular details when designing drugs to curb transmission of this biological armament.
【저자키워드】 COVID-19, coronavirus, pandemic, 2019-nCoV, virus, RNA, bats, 【초록키워드】 SARS-CoV-2, Vaccine, Pneumonia, COVID-19 pandemic, Diagnosis, Transmission, drug, coronavirus 2, non-structural proteins, viral genomes, Scientific community, molecular, novel, respiratory, pp1a, cellular, ORF1ab, open reading frames, shielding, Repository, sequence, polyprotein, spike trimer, pp1ab, Host, feature, glycosylation site, unique, translational, seeking, self-cleavage, 【제목키워드】 Basis, Pandora, the SARS-CoV-2, Unpacking,