Cytokine storm is a phenomenon characterized by strong elevated circulating cytokines that most often occur after an overreactive immune system is activated by an acute systemic infection. A variety of cells participate in cytokine storm induction and progression, with profiles of cytokines released during cytokine storm varying from disease to disease. This review focuses on pathophysiological mechanisms underlying cytokine storm induction and progression induced by pathogenic invasive infectious diseases. Strategies for targeted treatment of various types of infection-induced cytokine storms are described from both host and pathogen perspectives. In summary, current studies indicate that cytokine storm-targeted therapies can effectively alleviate tissue damage while promoting the clearance of invading pathogens. Based on this premise, “multi-omics” immune system profiling should facilitate the development of more effective therapeutic strategies to alleviate cytokine storms caused by various diseases.
【저자키워드】 Inflammation, Cytokine storm, Infectious disease, Treatment strategies, pathophysiological mechanism, 【초록키워드】 Treatment, therapy, Diseases, Infection, Strategy, cytokine, progression, immune system, pathogen, disease, therapeutic strategy, tissue damage, profile, pathogenic, invading pathogens, clearance, Host, effective, Cell, invasive, described, caused, elevated, facilitate, characterized, activated, occur, variety, released, alleviate, circulating cytokine, 【제목키워드】 induced, storm,