In several central nervous system diseases, it has been reported that inflammation may be related to the etiologic process, therefore, therapeutic strategies are being implemented to control inflammation. As the nervous system and the immune system maintain close bidirectional communication in physiological and pathological conditions, the modulation of inflammation through the cholinergic anti-inflammatory reflex has been proposed. In this review, we summarized the evidence supporting chemical stimulation with cholinergic agonists and vagus nerve stimulation as therapeutic strategies in the treatment of various central nervous system pathologies, and their effect on inflammation.
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【저자키워드】 Parkinson’s disease, Alzheimer’s disease, Vagus nerve stimulation, neuroimmunomodulation, nicotine receptor, experimental autoimmune encephalomyelitis, 【초록키워드】 Treatment, Inflammation, Diseases, Anti-inflammatory, immune system, nervous system, bidirectional, Central nervous system, Pathologies, therapeutic strategy, Evidence, physiological, modulation, agonist, pathological conditions, reported, maintain, nerve stimulation, 【제목키워드】 cholinergic, System, role, nervous, reflex,
【저자키워드】 Parkinson’s disease, Alzheimer’s disease, Vagus nerve stimulation, neuroimmunomodulation, nicotine receptor, experimental autoimmune encephalomyelitis, 【초록키워드】 Treatment, Inflammation, Diseases, Anti-inflammatory, immune system, nervous system, bidirectional, Central nervous system, Pathologies, therapeutic strategy, Evidence, physiological, modulation, agonist, pathological conditions, reported, maintain, nerve stimulation, 【제목키워드】 cholinergic, System, role, nervous, reflex,