Rapid and precise diagnostic methods are required to control emerging infectious diseases effectively. Human body fluids are attractive clinical samples for discovering diagnostic targets because they reflect the clinical statuses of patients and most of them can be obtained with minimally invasive sampling processes. Body fluids are good reservoirs for infectious parasites, bacteria, and viruses. Therefore, recent clinical proteomics methods have focused on body fluids when aiming to discover human- or pathogen-originated diagnostic markers. Cutting-edge liquid chromatography–mass spectrometry (LC-MS)-based proteomics has been applied in this regard; it is considered one of the most sensitive and specific proteomics approaches. Here, the clinical characteristics of each body fluid, recent tandem mass spectroscopy (MS/MS) data-acquisition methods, and applications of body fluids for proteomics regarding infectious diseases (including the coronavirus disease of 2019 [COVID-19]), are summarized and discussed.
【저자키워드】 COVID-19, proteomics, mass spectrometry, Infectious disease, pathogen, Biomarker discovery, bodily fluid, 【초록키워드】 coronavirus disease, viruses, Clinical characteristics, diagnostic, parasites, Patient, Rapid, target, Bacteria, Diagnostic method, human body, body fluid, approaches, reservoir, mass spectroscopy, invasive, clinical sample, required, applied, 【제목키워드】 review, liquid, Body,