The outbreak of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has led to coronavirus disease-19 (COVID-19); a pandemic disease that has resulted in devastating social, economic, morbidity and mortality burdens. SARS-CoV-2 infects cells following receptor-mediated endocytosis and priming by cellular proteases. Following uptake, SARS-CoV-2 replicates in autophagosome-like structures in the cytosol following its escape from endolysosomes. Accordingly, the greater endolysosome pathway including autophagosomes and the mTOR sensor may be targets for therapeutic interventions against SARS-CoV-2 infection and COVID-19 pathogenesis. Naturally existing compounds (phytochemicals) through their actions on endolysosomes and mTOR signaling pathways might provide therapeutic relief against COVID-19. Here, we discuss evidence that some natural compounds through actions on the greater endolysosome system can inhibit SARS-CoV-2 infectivity and thereby might be repurposed for use against COVID-19.
【저자키워드】 COVID-19, SARS-CoV-2, autophagy, natural compounds, Endolysosomes, 【초록키워드】 Structure, SARS-COV-2 infection, COVID-19 pathogenesis, Coronavirus disease-19, outbreak, therapeutic, pathway, target, morbidity and mortality, Evidence, Compound, therapeutic intervention, priming, cellular proteases, pandemic disease, cytosol, infect, mTOR signaling, Cell, endolysosome, greater, replicate, Naturally, inhibit SARS-CoV-2, 【제목키워드】 natural, Compound, Against,