Abstract SARS‐CoV‐2 entry is mediated by binding of the spike protein (S) to the surface receptor ACE2 and subsequent priming by host TMPRSS2 allowing membrane fusion. Here, we produced extracellular vesicles (EVs) exposing ACE2 and demonstrate that ACE2‐EVs are efficient decoys for SARS‐CoV‐2 S protein‐containing lentivirus. Reduction of infectivity positively correlates with the level of ACE2, is much more efficient than with soluble ACE2 and further enhanced by the inclusion of TMPRSS2.
All Keywords
【저자키워드】 ACE2, SARS‐CoV‐2, EV therapy, TMPRSS2, 【초록키워드】 SARS‐CoV‐2, lentivirus, membrane fusion, extracellular vesicle, binding, soluble ACE2, priming, surface receptor, Host, Inclusion, EVs, produced, subsequent, the spike protein, 【제목키워드】 Infection, virus, SARS‐CoV‐2 spike, Vesicle, Prevent,
【저자키워드】 ACE2, SARS‐CoV‐2, EV therapy, TMPRSS2, 【초록키워드】 SARS‐CoV‐2, lentivirus, membrane fusion, extracellular vesicle, binding, soluble ACE2, priming, surface receptor, Host, Inclusion, EVs, produced, subsequent, the spike protein, 【제목키워드】 Infection, virus, SARS‐CoV‐2 spike, Vesicle, Prevent,