Background and Aim: Although severe acute respiratory syndrome coronavirus 2 primarily affects the respiratory system, involvement of cardiovascular system is not uncommon and a range of cardiac manifestations among Coronavirus Disease (COVID-19) patients were reported in the literature. Furthermore, it is evident from scientific literature that the incidence of deaths and hospitalizations has been increasingly more among COVID-19 subjects with pre-existing cardiovascular disease (CVD). Various pathophysiological mechanisms have been proposed to explain the cardiovascular involvement in COVID-19. Another emerging significant concern is the varying presentations of COVID-19 and side effects due to the medication used in the management of COVID-19 patients. This review attempts to provide a comprehensive overview of the existing literature on the possible association between CVD and COVID-19 with emphasis on the pathophysiological mechanisms, cardiac manifestations, and impact of medications used for COVID-19 on cardiovascular health. Based on the available literature, we conclude that though CVD could not be reckoned as an independent risk factor for COVID-19 infection, it is evident that pre-existing CVD has an influence on the severity of COVID-19 infection and associated mortality. Relevance for Patients: Literature suggests that people with pre-existing CVD are at increased risk for COVID-19 and associated severity. Consequently, it becomes important to thoroughly gain insights into the possible pathophysiological mechanisms, cardiac manifestations in COVID-19, and the impact of COVID-19 treatment on the cardiovascular system.
【저자키워드】 severe acute respiratory syndrome coronavirus 2, myocardial injury, Thromboembolism, 【초록키워드】 COVID-19, Treatment, coronavirus, Mortality, Hospitalization, severity, Infection, cardiovascular disease, cardiovascular system, COVID-19 infection, severity of COVID-19, management, Patient, death, Manifestations, Respiratory system, incidence, literature, medication, COVID-19 patients, association, Cardiovascular health, manifestation, CVD, acute respiratory syndrome, Side effect, increased risk, subject, pathophysiological mechanism, independent risk factor, pathophysiological mechanisms, Affect, reported, explain, increasingly, Relevance, 【제목키워드】 review, cardiovascular, literature,