[저자] Julien Ramillon, Xavier de Lamballerie, Olivier Robineau, Hélène Blanché, Gianluca Severi, Mathilde Touvier, Marie Zins, Fabrice Carrat, the SAPRIS-SERO study groupAncelPierre-YvesCharlesMarie-AlineKabSofianeRenuyAdelineLe-GotStéphaneRibetCélineWiernikEmmanuelGoldbergMarcelArtaudFannyGerbouin-RérollePascaleEnguixMelodyLaplancheCamilleGomes-RimaRoselynHoangLyanCorreiaEmmanuelleBarryAlpha AmadouSeninaNadègeSzabo de EdelenyiFabienDruesne-PecolloNathalieEsseddikYounesHercbergSergeBenhammouValérieRitmiAnassMarchandLaetitiaZarosCécileLordmiElodieCandeaAdrianade VismeSophieSimeonThierryThierryXavierGeayBertrandDufourgMarie-NoëlleMilcentKarenLusivika-NzingaClovisPannetierGregoryLapidusNathanaelGoderelIsabelleDorivalCélineNicolJérômeLaiCindyEsperouHélèneCouffin-CadierguesSandrineGaglioloJean-MarieSebaounJean-MarcBeaudoinJean-ChristopheGressinLaetitiaMorelValérieOuiliOuissamDeleuzeJean-FrancoisPrietStephaneSaba VillarroelPaola MarielaFouriéToscaneMohamed AliSouandAmrounAbdenourSestonMorganAyhanNazliPastorinoBorisPellicerMireille AllegreJulienDeschasauxMélanieRahibDelphineLydieNathalieRobineauOlivierBelhadjiLizaNinoveLaetitia, Pierre-Yves Ancel, Marie-Aline Charles, Sofiane Kab, Adeline Renuy, Stéphane Le-Got, Céline Ribet, Emmanuel Wiernik, Marcel Goldberg, Fanny Artaud, Pascale Gerbouin-Rérolle, Melody Enguix, Camille Laplanche, Roselyn Gomes-Rima, Lyan Hoang, Emmanuelle Correia, Alpha Amadou Barry, Nadège Senina, Fabien Szabo de Edelenyi, Nathalie Druesne-Pecollo, Younes Esseddik, Serge Hercberg, Valérie Benhammou, Anass Ritmi, Laetitia Marchand, Cécile Zaros, Elodie Lordmi, Adriana Candea, Sophie de Visme, Thierry Simeon, Xavier Thierry, Bertrand Geay, Marie-Noëlle Dufourg, Karen Milcent, Clovis Lusivika-Nzinga, Gregory Pannetier, Nathanael Lapidus, Isabelle Goderel, Céline Dorival, Jérôme Nicol, Cindy Lai, Hélène Esperou, Sandrine Couffin-Cadiergues, Jean-Marie Gagliolo, Jean-Marc Sebaoun, Jean-Christophe Beaudoin, Laetitia Gressin, Valérie Morel, Ouissam Ouili, Jean-Francois Deleuze, Stephane Priet, Paola Mariela Saba Villarroel, Toscane Fourié, Souand Mohamed Ali, Abdenour Amroun, Morgan Seston, Nazli Ayhan, Boris Pastorino, Mireille Pellicer, Julien Allegre, Mélanie Deschasaux, Delphine Rahib, Nathalie Lydie, Olivier Robineau, Liza Belhadji, Laetitia Ninove, the SAPRIS study groupBajosNathalieAncelPierre-YvesCharlesMarie-AlineJusotFlorenceMartinClaudeMeyerLaurencePailheArianeSpireAlexisRouquetteAlexandra, Nathalie Bajos, Pierre-Yves Ancel, Marie-Aline Charles, Florence Jusot, Claude Martin, Laurence Meyer, Ariane Pailhe, Alexis Spire, Alexandra Rouquette, Nathanaël Lapidus
[Category] update2024,
[Article Type] article
[Source] pmc
Background Taste or smell disorders have been reported as strongly associated with COVID-19 diagnosis. We aimed to identify subject characteristics, symptom associations, and antibody response intensity associated with taste or smell disorders. Methods We used data from SAPRIS, a study based on a consortium of five prospective cohorts gathering 279,478 participants in the French general population. In the analysis, we selected participants who were presumably infected by SARS-CoV-2 during the first epidemic wave. Results The analysis included 3,439 patients with a positive ELISA-Spike. Sex (OR = 1.28 [95% CI 1.05–1.58] for women), smoking (OR = 1.54 [95% CI 1.13–2.07]), consumption of more than 2 drinks of alcohol a day (OR = 1.37 [95% CI 1.06–1.76]) were associated with a higher probability of taste or smell disorders. The relationship between age and taste or smell disorders was non-linear. Serological titers were associated with taste or smell disorders: OR = 1.31 [95% CI 1.26–1.36], OR = 1.37 [95% CI 1.33–1.42] and OR = 1.34 [95% CI 1.29–1.39] for ELISA-Spike, ELISA-Nucleocapsid and seroneutralization, respectively. Among participants with taste or smell disorders, 90% reported a wide variety of other symptoms whereas 10% reported no other symptom or only rhinorrhea. Conclusions Among patients with a positive ELISA-Spike test, women, smokers and people drinking more than 2 drinks a day were more likely to develop taste or smell disorders. This symptom was strongly associated with an antibody response. The overwhelming majority of patients with taste or smell disorders experienced a wide variety of symptoms. Supplementary Information The online version contains supplementary material available at 10.1186/s12879-023-08162-7.
All Keywords
【저자키워드】 SARS-CoV-2, COVID-19 serological testing, General population, smell disorders, taste disorders,