Background The new coronavirus disease COVID-19 began in December 2019 and has spread rapidly by human-to-human transmission. This study evaluated the transmissibility of the infectious disease and analyzed its association with temperature and humidity to study the propagation pattern of COVID-19. Methods In this study, we revised the reported data in Wuhan based on several assumptions to estimate the actual number of confirmed cases considering that perhaps not all cases could be detected and reported in the complex situation there. Then we used the equation derived from the Susceptible-Exposed-Infectious-Recovered (SEIR) model to calculate R 0 from January 24, 2020 to February 13, 2020 in 11 major cities in China for comparison. With the calculation results, we conducted correlation analysis and regression analysis between R 0 and temperature and humidity for four major cities in China to see the association between the transmissibility of COVID-19 and the weather variables. Results It was estimated that the cumulative number of confirmed cases had exceeded 45 000 by February 13, 2020 in Wuhan. The average R 0 in Wuhan was 2.7, significantly higher than those in other cities ranging from 1.8 to 2.4. The inflection points in the cities outside Hubei Province were between January 30, 2020 and February 3, 2020, while there had not been an obvious downward trend of R 0 in Wuhan. R 0 negatively correlated with both temperature and humidity, which was significant at the 0.01 level. Conclusions The transmissibility of COVID-19 was strong and importance should be attached to the intervention of its transmission especially in Wuhan. According to the correlation between R 0 and weather, the spread of disease will be suppressed as the weather warms.
【저자키워드】 COVID-19, Transmissibility, basic reproduction number, temperature, Humidity, 【초록키워드】 Intervention, Transmission, Infectious disease, Spread, China, Wuhan, correlation, disease, association, New coronavirus, regression analysis, confirmed case, Correlation analysis, complex, average, human-to-human transmission, assumption, cumulative, SEIR, Result, analyzed, reported, evaluated, conducted, correlated, significantly higher, suppressed, exceeded, calculate, variables, 【제목키워드】 China, Shanghai, association, Guangzhou, Beijing,