Spain is one of the countries most affected by the COVID-19 pandemic. Although risk factors for severe disease are published, sex differences have been widely neglected. In this multicentre study, we aimed to identify predictors of in-hospital mortality in men and women hospitalised with COVID-19. An observational longitudinal study was conducted in the cohort of patients admitted to four hospitals in Andalusia, Spain, from 1 March 2020 to 15 April 2020. Sociodemographic and clinical data were collected from hospital records. The Kaplan–Meier method was used to estimate 30-day survival and multiple Cox regression models were applied. All analyses were stratified by sex. A total of 968 patients were included (54.8% men, median age 67.0 years). In-hospital mortality reached 19.1% in men and 16.0% in women. Factors independently associated with an increased hazard of death were advanced age, higher CURB-65 score and not receiving azithromycin treatment, in both sexes; active cancer and autoimmune disease, in men; cardiovascular disease and chronic lung disease, in women. Disease outcomes and predictors of death differed between sexes. In-hospital mortality was higher in men, but the long-term effects of COVID-19 merit further research. The sex-differential impact of the pandemic should be addressed in public health policies.
【저자키워드】 COVID-19, SARS-CoV-2, Risk factors, Sex, Hospital mortality, 【초록키워드】 public health, pandemic, Mortality, COVID-19 pandemic, hospital, Lung disease, cardiovascular disease, outcome, risk factor, Autoimmune disease, survival, Research, Patient, Spain, death, multicentre, women, predictor, Sex difference, in-hospital mortality, CURB-65 score, Analysis, severe disease, Factor, Clinical data, median age, azithromycin treatment, advanced age, active cancer, Kaplan–Meier method, Effect, men, hospitalised, country, identify, affected, was used, collected, conducted, receiving, applied, reached, addressed, men and women, cohort of patient, multiple Cox regression, stratified by sex, with COVID-19, 【제목키워드】 difference, Result,