[저자] Joann Diray-Arce, Slim Fourati, Naresh Doni Jayavelu, Ravi Patel, Cole Maguire, Ana C. Chang, Ravi Dandekar, Jingjing Qi, Brian H. Lee, Patrick van Zalm, Andrew Schroeder, Ernie Chen, Anna Konstorum, Anderson Brito, Jeremy P. Gygi, Alvin Kho, Jing Chen, Shrikant Pawar, Ana Silvia Gonzalez-Reiche, Annmarie Hoch, Carly E. Milliren, James A. Overton, Kerstin Westendorf, IMPACC NetworkAbrahamJamesAdkissonMichaelAlbertMarisaAltamirano TorresLuzAlvarengaBonnyAndersonMatthew L.AndersonEvan J.ArnettAzlannAsashimaHiromitsuAtkinsonMark A.BadenLindsey R.BartonBrendaBeachKatherineBeagleElizabethBeckerPatrice M.BellMatthew R.BernuiMarianaBimeChrisBoddapati KumarArunBoothLeland J.BorresenBrittneyBrakenridgeScott C.BristowLaurelBryantRobertCalfeeCarolyn S.Carreño ManuelJuanCarrilloSidneyChakSuzannaChangIrisConnorsJenniferConwayMichelleCorryDavid B.CowanDavidCroenBrettDela CruzCharles S.CusimanoGinaEakerLilyEdwardsCarolynEhrlichLauren I.R.ElashoffDavidEricksonHeidiErleDavid J.FarhadianShelliFarrugiaKeithFatouBenoitFernandesAndreaFernandez-SesmaAnaFragiadakisGabriela K.FurukawaSaraGeltmanJanelle N.GhaleRajaniGonzález Carolina BermúdezMariaGoonewardeneMichael I.Guerrero SanchezEstellaGuirgisFaheem W.HaflerDavid A.HamiltonSydneyHarrisPaulHayati NematiArashHendricksonCarolyn M.Higuita AgudeloNelson I.HodderThomasHollandSteven M.HoughCatherine L.HuertaChristopherHurleyKerin C.HuttonScott R.IwasakiAkikoJaureguiAlejandraJhaMeenakshiJohnsonBrandiJoynerDavidKangelarisKirsten N.KellyGeoffreyKhalilZainKhanZenabKheradmandFarrahKimJames N.KimuraHirokiKoAlbert I.KohrBernardKraftMonicaKrummelMatthewKutzlerMichele F.Lasky-SuJessicaLeeSerenaLeeDeannaLeipoldMichaelLentucciClaudiaLerouxCarolynLinEdwardLiuShanshanLoveChristinaLuZhengchunMaliskovaLenkaManning RothBrittanyManoharMonaliMartensMarkMcComseyGrace A.McEnaneyKerryMcLinReneeMelamedEstherMelnykNataliyaMendezKevinMesserWilliam B.MetcalfJordan P.MichelottiGregoryMickEranMohantySubhasisMosierJarrodMulderLubbertus C.F.MurphyMaimounaNadeauKari R.C.NelsonEbonyNelsonAllisonNguyenVietOberhausJordanPanganibanBernadinePellegriniKathryn L.PickeringHarry C.PowellDebra L.PresnellScottPulendranBaliRahmanAdeeb H.Rashid SadeedAhmadRaskinArielReedElaine F.Ribeiro PereiraSusanRiveraAdreanne M.RogersJacob E.RogersAngelaRogowskiBrandonRooksRebeccaRosenberg-HassonYaelRothmanJessicaRousseauJustin F.Salehi-RadRaminSaluvanMehmetSamahaHadySchaenmanJoannaSchunkRonSemenzaNicholas C.SenSubhaSevranskyJonathanSeyfert-MargolisVickiShaheenTanziaShawAlbert C.SiegScottSiegelSarah A.R.SigalNataliaSilesNadiaSimmonsBrentSimonVivianaSinghGagandeepSinkoLaurenSmithCecilia M.SmolenKinga K.SongLi-ZhenSrivastavaKomalSullivanPeterSyphursCaitlinTcheouJohnstoneTegosGeorge P.TharpGreg K.Tong AllyAlexandraTsitsiklisAlexandraUngaroRicardo F.VaysmanTatyanaViodeArthurVitaRandiWangXiaomeiWardAlyssaWardDawn C.WillmoreAndrewWoloszczukKyraWongKariWoodruffPrescott G.XuLeqivan HarenSimonvan de GuchteAdrianaZhaoYujiao, James Abraham, Michael Adkisson, Marisa Albert, Luz Altamirano Torres, Bonny Alvarenga, Matthew L. Anderson, Evan J. Anderson, Azlann Arnett, Hiromitsu Asashima, Mark A. Atkinson, Lindsey R. Baden, Brenda Barton, Katherine Beach, Elizabeth Beagle, Patrice M. Becker, Matthew R. Bell, Mariana Bernui, Chris Bime, Arun Boddapati Kumar, Leland J. Booth, Brittney Borresen, Scott C. Brakenridge, Laurel Bristow, Robert Bryant, Carolyn S. Calfee, Juan Carreño Manuel, Sidney Carrillo, Suzanna Chak, Iris Chang, Jennifer Connors, Michelle Conway, David B. Corry, David Cowan, Brett Croen, Charles S. Dela Cruz, Gina Cusimano, Lily Eaker, Carolyn Edwards, Lauren I.R. Ehrlich, David Elashoff, Heidi Erickson, David J. Erle, Shelli Farhadian, Keith Farrugia, Benoit Fatou, Andrea Fernandes, Ana Fernandez-Sesma, Gabriela K. Fragiadakis, Sara Furukawa, Janelle N. Geltman, Rajani Ghale, Maria González Carolina Bermúdez, Michael I. Goonewardene, Estella Guerrero Sanchez, Faheem W. Guirgis, David A. Hafler, Sydney Hamilton, Paul Harris, Arash Hayati Nemati, Carolyn M. Hendrickson, Nelson I. Higuita Agudelo, Thomas Hodder, Steven M. Holland, Catherine L. Hough, Christopher Huerta, Kerin C. Hurley, Scott R. Hutton, Akiko Iwasaki, Alejandra Jauregui, Meenakshi Jha, Brandi Johnson, David Joyner, Kirsten N. Kangelaris, Geoffrey Kelly, Zain Khalil, Zenab Khan, Farrah Kheradmand, James N. Kim, Hiroki Kimura, Albert I. Ko, Bernard Kohr, Monica Kraft, Matthew Krummel, Michele F. Kutzler, Jessica Lasky-Su, Serena Lee, Deanna Lee, Michael Leipold, Claudia Lentucci, Carolyn Leroux, Edward Lin, Shanshan Liu, Christina Love, Zhengchun Lu, Lenka Maliskova, Brittany Manning Roth, Monali Manohar, Mark Martens, Grace A. McComsey, Kerry McEnaney, Renee McLin, Esther Melamed, Nataliya Melnyk, Kevin Mendez, William B. Messer, Jordan P. Metcalf, Gregory Michelotti, Eran Mick, Subhasis Mohanty, Jarrod Mosier, Lubbertus C.F. Mulder, Maimouna Murphy, Kari R.C. Nadeau, Ebony Nelson, Allison Nelson, Viet Nguyen, Jordan Oberhaus, Bernadine Panganiban, Kathryn L. Pellegrini, Harry C. Pickering, Debra L. Powell, Scott Presnell, Bali Pulendran, Adeeb H. Rahman, Ahmad Rashid Sadeed, Ariel Raskin, Elaine F. Reed, Susan Ribeiro Pereira, Adreanne M. Rivera, Jacob E. Rogers, Angela Rogers, Brandon Rogowski, Rebecca Rooks, Yael Rosenberg-Hasson, Jessica Rothman, Justin F. Rousseau, Ramin Salehi-Rad, Mehmet Saluvan, Hady Samaha, Joanna Schaenman, Ron Schunk, Nicholas C. Semenza, Subha Sen, Jonathan Sevransky, Vicki Seyfert-Margolis, Tanzia Shaheen, Albert C. Shaw, Scott Sieg, Sarah A.R. Siegel, Natalia Sigal, Nadia Siles, Brent Simmons, Viviana Simon, Gagandeep Singh, Lauren Sinko, Cecilia M. Smith, Kinga K. Smolen, Li-Zhen Song, Komal Srivastava, Peter Sullivan, Caitlin Syphurs, Johnstone Tcheou, George P. Tegos, Greg K. Tharp, Alexandra Tong Ally, Alexandra Tsitsiklis, Ricardo F. Ungaro, Tatyana Vaysman, Arthur Viode, Randi Vita, Xiaomei Wang, Alyssa Ward, Dawn C. Ward, Andrew Willmore, Kyra Woloszczuk, Kari Wong, Prescott G. Woodruff, Leqi Xu, Simon van Haren, Adriana van de Guchte, Yujiao Zhao, Charles B. Cairns, Nadine Rouphael, Steven E. Bosinger, Seunghee Kim-Schulze, Florian Krammer, Lindsey Rosen, Nathan D. Grubaugh, Harm van Bakel, Michael Wilson, Jayant Rajan, Hanno Steen, Walter Eckalbar, Chris Cotsapas, Charles R. Langelier, Ofer Levy, Matthew C. Altman, Holden Maecker, Ruth R. Montgomery, Elias K. Haddad, Rafick P. Sekaly, Denise Esserman, Al Ozonoff, Patrice M. Becker, Alison D. Augustine, Leying Guan, Bjoern Peters, Steven H. Kleinstein
[Category] update2024,
[Article Type] article
[Source] pmc
Summary The IMPACC cohort, composed of >1,000 hospitalized COVID-19 participants, contains five illness trajectory groups (TGs) during acute infection (first 28 days), ranging from milder (TG1–3) to more severe disease course (TG4) and death (TG5). Here, we report deep immunophenotyping, profiling of >15,000 longitudinal blood and nasal samples from 540 participants of the IMPACC cohort, using 14 distinct assays. These unbiased analyses identify cellular and molecular signatures present within 72 h of hospital admission that distinguish moderate from severe and fatal COVID-19 disease. Importantly, cellular and molecular states also distinguish participants with more severe disease that recover or stabilize within 28 days from those that progress to fatal outcomes (TG4 vs. TG5). Furthermore, our longitudinal design reveals that these biologic states display distinct temporal patterns associated with clinical outcomes. Characterizing host immune responses in relation to heterogeneity in disease course may inform clinical prognosis and opportunities for intervention. Graphical abstract Highlights • Distinct baseline and temporal patterns are associated with the clinical course • Persistent viral levels, despite high antibody titers, are associated with severity • Severity is linked to reduced cytotoxic NK cells, increased inflammation, and thrombosis • Myocardial damage markers distinguish critical patients who recover from those who die Diray-Arce et al. conduct deep immunophenotyping of acute COVID-19 infection using more than 15,000 longitudinal samples from 540 hospitalized patients in the IMPACC cohort. The study comprehensively defines baseline and longitudinal immunologic states that are associated with mild to fatal disease trajectory groups.
All Keywords
【저자키워드】 COVID-19, SARS-CoV-2, Immunophenotyping, systems immunology, Multi-omics, longitudinal modeling,