We aimed to investigate whether comorbid musculoskeletal disorders (MSD)s and pain medication use was associated with in-hospital mortality among patients with coronavirus disease 2019 (COVID-19). Adult patients (≥20 years old) with a positive COVID-19 diagnosis until 5 June 2020 were included in this study, based on the National Health Insurance COVID-19 database in South Korea. MSDs included osteoarthritis, neck pain, lower back pain, rheumatoid arthritis, and others, while pain medication included paracetamol, gabapentin, pregabalin, glucocorticoid, nonsteroidal anti-inflammatory drugs (NSAIDs), opioids (strong and weak opioids), and benzodiazepine. Primary endpoint was in-hospital mortality. A total of 7713 patients with COVID-19 were included, and in-hospital mortality was observed in 248 (3.2%) patients. In multivariate logistic regression analysis, no MSDs ( p > 0.05) were significantly associated with in-hospital mortality. However, in-hospital mortality was 12.73 times higher in users of strong opioids (odds ratio: 12.73, 95% confidence interval: 2.44–16.64; p = 0.002), while use of paracetamol ( p = 0.973), gabapentin or pregabalin ( p = 0.424), glucocorticoid ( p = 0.673), NSAIDs ( p = 0.979), weak opioids ( p = 0.876), and benzodiazepine ( p = 0.324) was not associated with in-hospital mortality. In South Korea, underlying MSDs were not associated with increased in-hospital mortality among patients with COVID-19. However, use of strong opioids was significantly associated with increased in-hospital mortality among the patients.
【저자키워드】 Population, opioid, Pain, analgesics, musculoskeletal diseases, 【초록키워드】 COVID-19, coronavirus disease, Diagnosis, database, glucocorticoid, rheumatoid arthritis, NSAIDS, Patient, Osteoarthritis, medication, South Korea, patients, in-hospital mortality, NSAID, Analysis, Paracetamol, insurance, Musculoskeletal, Endpoint, nonsteroidal anti-inflammatory drug, multivariate logistic regression, disorder, positive COVID-19, Neck pain, significantly, Adult patient, lower back, MSD, patients with COVID-19, 【제목키워드】 South, with COVID-19,