Lactobacillus acidophilus and propionate attenuate Sjögren’s syndrome by modulating the STIM1-STING signaling pathway

Background Sjögren’s syndrome (SS) is an autoimmune disease characterized by inflammation of the exocrine gland. An imbalance of gut microbiota has been linked to SS. However, the molecular mechanism is unclear. We investigated the effects of Lactobacillus acidophilus ( L . acidophilus ) and propionate on the development and progression of SS in mouse model. Methods We compared the gut microbiomes of young and old mice. We administered L . acidophilus and propionate up to 24 weeks. The saliva flow rate and the histopathology of the salivary glands were investigated, and the effects of propionate on the STIM1-STING signaling pathway were evaluated in vitro. Results Lactobacillaceae and Lactobacillus were decreased in aged mice. SS symptoms were ameliorated by L . acidophilus . The abundance of propionate-producing bacterial was increased by L . acidophilus . Propionate ameliorated the development and progression of SS by inhibiting the STIM1-STING signaling pathway. Conclusions The findings suggest that Lactobacillus acidophilus and propionate have therapeutic potential for SS. Video Abstract Supplementary Information The online version contains supplementary material available at 10.1186/s12964-023-01141-0.